I know GrafX2 has been discussed before, but I wasn't aware of the ability to script plugins in lua.
http://code.google.com/p/grafx2/
As an example, here's a script to reduce the palette in 8x1 cells (for the MSX):
http://karoshi.auic.es/index.php?topic=1901.0
This doesn't look that difficult to expand.
GrafX2
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